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The Use of Xylazine in Illicitly Manufactured Opioids


The Arkansas Department of Health, Section of Emergency Medical Services, has issued new information about the use of xylazine in illicitly manufactured opioids.

In addition to high-potency opioids, xylazine is now being used as an adulterant compound in illegally produced opioids. Xylazine, a non-opioid alpha-adrenergic agonist, is legally administered to animals by veterinarians as a sedative, anesthetic, muscle relaxant and analgesic. In humans, xylazine can cause respiratory depression, bradycardia, various forms of heart block, and death. A Drug Enforcement Administration (DEA) license is not required to obtain xylazine, and this factor makes the drug more readily accessible.

Read the full memorandum here.